Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial.
@article{Cummings1998EffectOA, title={Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial.}, author={Steven R. Cummings and Dennis M. Black and Desmond E Thompson and William B. Applegate and Elizabeth Barrett-Connor and Thomas A. Musliner and Lisa Palermo and Ronald Prineas and Susan M. Rubin and J C Scott and Thomas M. Vogt and Robert B. Wallace and A. John Yates and Andrea Z. LaCroix}, journal={JAMA}, year={1998}, volume={280 24}, pages={ 2077-82 } }
CONTEXT
Alendronate sodium reduces fracture risk in postmenopausal women who have vertebral fractures, but its effects on fracture risk have not been studied for women without vertebral fractures. [] Key MethodDESIGN
Randomized, blinded, placebo-controlled trial.
SETTING
Eleven community-based clinical research centers.
2,306 Citations
Effect of alendronate on vertebral fracture risk in women with bone mineral density T scores of-1.6 to -2.5 at the femoral neck: the Fracture Intervention Trial.
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In women with low bone mass who do not meet the bone mineral density criterion for osteoporosis, alendronate is effective in reducing the risk of vertebral fractures.
Fracture risk reduction with alendronate in women with osteoporosis: the Fracture Intervention Trial. FIT Research Group.
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Reductions in fracture risk during treatment with alendronate are consistent in women with existing vertebral fractures and those without such fractures but with bone mineral density in the osteoporotic range.
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Denosumab reduced the incidence of new vertebral and hip fractures in postmenopausal women with osteoporosis at higher risk for fracture, and these results highlight the consistent antifracture efficacy of denosumAB in patients with varying degrees of fracture risk.
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Among patients who adhere to treatment with alendronate, even those who lose BMD benefit from a substantial reduction in risk of vertebral fracture, and the reduction in bone turnover induced by alendronsate might be more important than BMD changes.
Larger increases in bone mineral density during alendronate therapy are associated with a lower risk of new vertebral fractures in women with postmenopausal osteoporosis. Fracture Intervention Trial Research Group.
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Women with increases of > or =3% in BMD during the first 1 or 2 years of alendronate treatment had the lowest incidence of new vertebral fractures, suggesting that, among women taking antiresorptive agents, greater increases in B MD are associated with lower risk of new fractures.
Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double-blind, placebo-controlled trial in elderly women.
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BACKGROUND
Increased dietary calcium intake has been proposed as a population-based public health intervention to prevent osteoporotic fractures. We have examined whether calcium supplementation…
Comparative effects of raloxifene and alendronate on fracture outcomes in postmenopausal women with low bone mass.
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a repository copy of Pharmacologic intervention for prevention of fractures in osteopenic and osteoporotic postmenopausal women: Systemic review and meta-analysis
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Overall results of limited studies for non-bisphosphonate drugs showed increased BMD and raloxifene signiicantly decreases the risk of subsequent clinical vertebral fractures in postmenopausal women with osteopenia or osteoporosis.
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Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group.
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The data suggest that risedronate therapy is effective and well tolerated in the treatment of women with established postmenopausal osteoporosis.
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