Effect of alendronate on fracture healing and bone remodeling in dogs.

@article{Peter1996EffectOA,
  title={Effect of alendronate on fracture healing and bone remodeling in dogs.},
  author={Clifton Peter and W O Cook and David M. Nunamaker and Marilou Provost and J. Gregory Seedor and Gideon A. Rodan},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={1996},
  volume={14 1},
  pages={74-9}
}
To examine the effect of alendronate (4-amino-1-hydroxybutylidene bisphosphonate) on fracture repair, the drug was given to mature beagle dogs orogastrically at 2 mg/kg/day for 9 weeks preceding fracture. 16 weeks after fracture, or both before and after fracture (25 weeks). A transverse mid-diaphyseal fracture of the right radius was surgically induced and was stabilized by external coaptation splinting. Fracture healing and bone remodeling were evaluated by radiography, gross and histological… CONTINUE READING

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Journal of orthopaedic research : official publication of the Orthopaedic Research Society • 2017
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