Effect of aldosterone antagonism on myocardial dysfunction in hypertensive patients with diastolic heart failure.

@article{Mottram2004EffectOA,
  title={Effect of aldosterone antagonism on myocardial dysfunction in hypertensive patients with diastolic heart failure.},
  author={Philip M. Mottram and Brian A. Haluska and Rodel L Leano and Diane C Cowley and Michael Stowasser and Thomas H Marwick},
  journal={Circulation},
  year={2004},
  volume={110 5},
  pages={558-65}
}
BACKGROUND Specific treatments targeting the pathophysiology of hypertensive heart disease are lacking. As aldosterone has been implicated in the genesis of myocardial fibrosis, hypertrophy, and dysfunction, we sought to determine the effects of aldosterone antagonism on myocardial function in hypertensive patients with suspected diastolic heart failure by using sensitive quantitative echocardiographic techniques in a randomized, double-blinded, placebo-controlled study. METHODS AND RESULTS… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 104 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 56 references

Similar Papers

Loading similar papers…