Effect of alcohol on the secretion of tumor necrosis factor-alpha by macrophages in the presence of rat serum.

Abstract

BACKGROUND It is suggested that endotoxin, proinflammatory cytokines, and lipopolysaccharide-binding protein (LBP) play an important role in the development of alcoholic liver disease. Our previous study showed that splenic macrophages were important for endotoxin uptake and excessive production of tumor necrosis factor (TNF) in rats given large amounts of… (More)

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