Effect of alcohol on drug efflux protein and drug metabolic enzymes in U937 macrophages.

@article{Jin2011EffectOA,
  title={Effect of alcohol on drug efflux protein and drug metabolic enzymes in U937 macrophages.},
  author={Mengyao Jin and Priyanka Arya and Kalpeshkumar H. Patel and Bhupendra Singh and Peter S. Silverstein and Hari K. Bhat and Anil Kumar and Santosh Kumar},
  journal={Alcoholism, clinical and experimental research},
  year={2011},
  volume={35 1},
  pages={
          132-9
        }
}
BACKGROUND ATP-binding cassette (ABC) proteins and cytochrome P450 (CYP) enzymes regulate the bioavailability of HIV-1 antiretroviral therapeutic drugs, non-nucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors (PIs). They are also involved in regulating, and responding to, oxidative stress in various tissues and organs including liver. This study is designed to assess the effect of alcohol on the ABCC1 and CYP enzymes involved in the metabolism of NNRTIs and PIs (CYP2B6… CONTINUE READING
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