Corpus ID: 38663005

Effect of albumin binding on the hepatic transport of rose bengal: surface-mediated dissociation of limited capacity.

@article{Forker1982EffectOA,
  title={Effect of albumin binding on the hepatic transport of rose bengal: surface-mediated dissociation of limited capacity.},
  author={E. L. Forker and B. Luxon and M. Snell and W. O. Shurmantine},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1982},
  volume={223 2},
  pages={
          342-7
        }
}
We have studied the steady-state removal of rose bengal by perfused rat livers to decide whether the tight association of this anion with albumin is consistent with the conventional view that only the free fraction in the sinusoidal lumen is available for hepatic transport. The results show that the concentration of free dye is not nearly high enough to account for the observed removal rate. From these observations we argue that the liver cell surface reduces the affinity of rose bengal for… Expand
View on PubMed
72 Citations
Highly Influential Citations
3
Background Citations
13
Methods Citations
2

72 Citations

Citation Type

Citation Type

Albumin-mediated transport of rose bengal by perfused rat liver. Kinetics of the reaction at the cell surface.
  • 82
  • PDF
Uptake of oleate from albumin solutions by rat liver. Failure to detect catalysis of the dissociation of oleate from albumin by an albumin receptor.
  • 81
  • PDF
Uptake of organic anions by hepatocyte monolayers: codiffusion versus facilitated dissociation.
  • 5
Characterization of Rose Bengal binding to sinusoidal and bile canalicular plasma membrane from rat liver.
  • 25
Kinetic analysis of albumin-mediated uptake of warfarin by perfused rat liver
  • 21
'Albumin-receptor' uptake kinetics do not require an intact lobular architecture and are not specific for albumin.
  • 32
Evaluation of Protein Binding Effect on Local Disposition of Oxacillin in Rat Liver by a Two‐compartment Dispersion Model
  • 19
Lactosylation of albumin reduces uptake rate of dibromosulfophthalein in perfused rat liver and dissociation rate from albumin In Vitro
  • 27
Effect of albumin on hepatic uptake of warfarin in normal and analbuminemic mutant rats: Analysis by multiple indicator dilution method
  • 21
Propranolol metabolism by isolated hepatocytes from normal and cirrhotic rat livers: the effect of albumin.
  • 6
...
1
2
3
4
5
...