Corpus ID: 38663005

Effect of albumin binding on the hepatic transport of rose bengal: surface-mediated dissociation of limited capacity.

@article{Forker1982EffectOA,
  title={Effect of albumin binding on the hepatic transport of rose bengal: surface-mediated dissociation of limited capacity.},
  author={E. L. Forker and B. Luxon and M. Snell and W. O. Shurmantine},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1982},
  volume={223 2},
  pages={
          342-7
        }
}
We have studied the steady-state removal of rose bengal by perfused rat livers to decide whether the tight association of this anion with albumin is consistent with the conventional view that only the free fraction in the sinusoidal lumen is available for hepatic transport. The results show that the concentration of free dye is not nearly high enough to account for the observed removal rate. From these observations we argue that the liver cell surface reduces the affinity of rose bengal for… Expand
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