Effect of airway acidosis and alkalosis on airway vascular smooth muscle responsiveness to albuterol

Abstract

In vitro and animal experiments have shown that the transport and signaling of β2-adrenergic agonists are pH-sensitive. Inhaled albuterol, a hydrophilic β2-adrenergic agonist, is widely used for the treatment of obstructive airway diseases. Acute exacerbations of obstructive airway diseases can be associated with changes in ventilation leading to either… (More)
DOI: 10.1186/s40360-015-0008-y

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