Effect of agrin on the distribution of acetylcholine receptors and sodium channels on adult skeletal muscle fibers in culture

@article{Lupa1991EffectOA,
  title={Effect of agrin on the distribution of acetylcholine receptors and sodium channels on adult skeletal muscle fibers in culture},
  author={M. Lupa and J. Caldwell},
  journal={The Journal of Cell Biology},
  year={1991},
  volume={115},
  pages={765 - 778}
}
We used the loose patch voltage clamp technique and rhodamine- conjugated alpha-bungarotoxin to study the regulation of Na channel (NaCh) and acetylcholine receptor (AChR) distribution on dissociated adult skeletal muscle fibers in culture. The aggregate of AChRs and NaChs normally found in the postsynaptic membrane of these cells gradually fragmented and dispersed from the synaptic region after several days in culture. This dispersal was the result of the collagenase treatment used to… Expand
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