Effect of agmatine on experimental vascular endothelial dysfunction.

  title={Effect of agmatine on experimental vascular endothelial dysfunction.},
  author={Manar A. Nader and N M Gamiel and Hassan A. El-kashef and Mohamed S Zaghloul},
  journal={Human & experimental toxicology},
  volume={35 5},
This study was designed to investigate the effect of agmatine sulfate (AG, CAS2482-00-0) in nicotine (NIC)-induced vascular endothelial dysfunction (VED) in rabbits. NIC was administered to produce VED in rabbits with or without AG for 6 weeks. Serum lipid profile, serum thiobarbituric acid reactive substances, reduced glutathione, superoxide dismutase generation, serum nitrite/nitrate, serum vascular cellular adhesion molecule-1 (VCAM-1), and aortic nuclear factor κB (NF-κB) levels were… CONTINUE READING