Effect of aging on the response of the cerebral cortex to noradrenergic denervation.


Cyclic AMP generation was measured in isolated minces of the ipsilateral and contralateral cortex of young (3-4 months) and aged (28-29 months) Fischer-344 rats, 2 weeks after unilateral lesion of the nucleus locus ceruleus (LC). Measurements were conducted under basal conditions and in the presence of 0.1 mM isoproterenol. Despite marked norepinephrine (NE… (More)


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