Effect of aging on the response of the cerebral cortex to noradrenergic denervation.

Abstract

Cyclic AMP generation was measured in isolated minces of the ipsilateral and contralateral cortex of young (3-4 months) and aged (28-29 months) Fischer-344 rats, 2 weeks after unilateral lesion of the nucleus locus ceruleus (LC). Measurements were conducted under basal conditions and in the presence of 0.1 mM isoproterenol. Despite marked norepinephrine (NE… (More)

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