Effect of aging on myocardial adenosine production, adenosine uptake and adenosine kinase activity in rats.

@article{Lorbar1999EffectOA,
  title={Effect of aging on myocardial adenosine production, adenosine uptake and adenosine kinase activity in rats.},
  author={Mojca Lorbar and Richard A. Fenton and Andrew John Duffy and Christopher Graybill and James G. Dobson},
  journal={Journal of molecular and cellular cardiology},
  year={1999},
  volume={31 2},
  pages={401-12}
}
Adenosine levels present in the interstitial fluid and coronary effluent of the aged heart exceed those of the young adult heart. The present study investigated mechanisms in the Fischer 344 rat heart which may be responsible for the observed differences. (1) Total production of adenosine was determined in isolated perfused hearts by measuring coronary… CONTINUE READING