Effect of aging on insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of rats.

@inproceedings{Carvalho1996EffectOA,
  title={Effect of aging on insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of rats.},
  author={Carla R.O. Carvalho and Sigisfredo Luis Brenelli and Andreia Lopes da Silva and Andr{\'e} Luiz Baptiston Nunes and L{\'i}cio Augusto Velloso and Mario J.A. Saad},
  year={1996}
}
Insulin stimulates the tyrosine kinase activity of its receptor, resulting in the phosphorylation of its cytosolic substrate, insulin receptor substrate-1 (IRS-1), which, in turn, associates with phosphatidylinositol 3-kinase (PI 3-kinase), thereby activating the latter. Aging is associated with insulin resistance, but the exact molecular mechanism is unknown. In the present study, we examined the levels and phosphorylation status of the insulin receptor and IRS-1 as well as the association… CONTINUE READING

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