Effect of aging on endothelium-dependent vascular relaxation of isolated human basilar artery to thrombin and bradykinin.

@article{Hatake1990EffectOA,
  title={Effect of aging on endothelium-dependent vascular relaxation of isolated human basilar artery to thrombin and bradykinin.},
  author={Katsuhiko Hatake and Eizo Kakishita and Ichiro Wakabayashi and Naoki Sakiyama and Shigeru Hishida},
  journal={Stroke},
  year={1990},
  volume={21 7},
  pages={1039-43}
}
Using strips of human basilar arteries mounted in organ chambers to record isometric tension, we investigated vascular reactivity to thrombin and bradykinin. Both agents produced endothelium-dependent relaxation of basilar artery strips precontracted with phenylephrine but had no effect on resting tension in strips with or without endothelium. The relaxations caused by thrombin were abolished by antithrombin III/heparin, hirudin, and MD805. Thrombin but not bradykinin caused complete… CONTINUE READING

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Comparison of the inhibitory effects of antithrombin III, a2-macroglobulin, and thrombin in human basilar arteries: Relevance to cerebral vasospasm

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