Effect of aging on cholesterol 7 alpha-hydroxylation in humans.

  title={Effect of aging on cholesterol 7 alpha-hydroxylation in humans.},
  author={Marco Bertolotti and Nicola Abate and Sonia G Bertolotti and Paola Dr Loria and Mauro Concari and R Messora and Francesca Carubbi and Adriano Pinetti and Nicola Carulli},
  journal={Journal of lipid research},
  volume={34 6},
In order to investigate the alterations of bile acid synthesis in aging, we studied the rates of cholesterol 7 alpha-hydroxylation, the rate-limiting step, in 28 patients of different ages (34-83 years old, 14 below and 14 above the age of 65) of both sexes. Hydroxylation rates were determined by tritium release assay after an intravenous bolus of [7 alpha-3H]cholesterol. Cholesterol 7 alpha-hydroxylation was significantly decreased in the older age group, compared to middle-aged subjects, both… CONTINUE READING


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