Effect of aging and obesity on insulin responsiveness and glut-4 glucose transporter content in skeletal muscle of Fischer 344 x Brown Norway rats.

@article{Larkin2001EffectOA,
  title={Effect of aging and obesity on insulin responsiveness and glut-4 glucose transporter content in skeletal muscle of Fischer 344 x Brown Norway rats.},
  author={Lisa M Larkin and Thomas H. Reynolds and Mark A. Supiano and Barbara B. Kahn and Jeffrey B. Halter},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2001},
  volume={56 11},
  pages={B486-92}
}
This study investigated the metabolic changes with age in the Fischer 344 x Brown Norway rat and its suitability as an animal model of postmaturational insulin resistance. Specifically, we determined whether an age-associated decrease in glucose disposal is associated with diminished whole body insulin responsiveness and/or a decrease in glucose transporter (GLUT-4) protein and mRNA content in medial gastrocnemius muscle of male Fischer 344 x Brown Norway rats of ages 8, 18, and 28 months… CONTINUE READING

From This Paper

Topics from this paper.
9 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…