Effect of age on burst firing characteristics of rat hippocampal pyramidal cells.

@article{Smith2000EffectOA,
  title={Effect of age on burst firing characteristics of rat hippocampal pyramidal cells.},
  author={Allan C Smith and Jason L Gerrard and Carol A. Barnes and Bruce L. McNaughton},
  journal={Neuroreport},
  year={2000},
  volume={11 17},
  pages={3865-71}
}
During behavior, hippocampal pyramidal cells emit high frequency bursts, modulated by the animal's location and the 7 Hz theta rhythm. During rest, CA1 EEG exhibits large irregular activity (LIA), containing sharp-wave/ripple complexes, during which pyramidal cells exhibit burst discharge. Aging results in altered intracellular calcium homeostasis, increased electrical coupling and reduced cholinergic modulation within CA1, all of which might affect burst discharge characteristics. During LIA… CONTINUE READING

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Moreover , age related changes in the cholinergic system appear not to play a major role in shaping the temporal discharge characteristics of CA1 pyramidal cells .
Moreover , age related changes in the cholinergic system appear not to play a major role in shaping the temporal discharge characteristics of CA1 pyramidal cells .
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