Effect of age on acute morphine response in the rat.


The importance of age as an experimental variable in the evaluation of the analgesic, thermic, and respiratory depressant effects to morphine was studied in male rats one and one-half, six, and ten months of age. Significant age-related responses were observed in both the analgesic and thermic responses to morphine. Also, following a dose of 30 mg/kg… (More)


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