Effect of age and weight on upper airway function in a mouse model.

  title={Effect of age and weight on upper airway function in a mouse model.},
  author={Mikhael Polotsky and Ahmed S Elsayed-Ahmed and Luis E Pichard and Ria A Richardson and Philip L. Smith and Hartmut Schneider and Jason P. Kirkness and Vsevolod Y Polotsky and Alan R. Schwartz},
  journal={Journal of applied physiology},
  volume={111 3},
Defects in pharyngeal mechanical and neuromuscular control are required for the development of obstructive sleep apnea. Obesity and age are known sleep apnea risk factors, leading us to hypothesize that specific defects in upper airway neuromechanical control are associated with weight and age in a mouse model. In anesthetized, spontaneously breathing young and old wild-type C57BL/6J mice, genioglossus electromyographic activity (EMG(GG)) was monitored and upper airway pressure-flow dynamics… CONTINUE READING
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