Effect of age and gender on the pharmacokinetics of ebastine after single and repeated dosing in healthy subjects.

@article{Rohatagi2001EffectOA,
  title={Effect of age and gender on the pharmacokinetics of ebastine after single and repeated dosing in healthy subjects.},
  author={Shashank S Rohatagi and Michael Gillen and M Aubeneau and Caroline Jan and Bhaswati Pandit and Bradford K Jensen and Gerald R. Rhodes},
  journal={International journal of clinical pharmacology and therapeutics},
  year={2001},
  volume={39 3},
  pages={126-34}
}
OBJECTIVES Ebastine is a potent and selective H1-receptor antagonist indicated for allergic rhinitis which undergoes extensive first pass metabolism by CYP3A4 to form an active metabolite, carebastine. The purpose of the study was to determine age- and gender-related differences in the pharmacokinetics of ebastine and carebastine. METHODS The upper recommended oral dose of 20 mg once daily was administered to 12 healthy young (22 to 38 years) and 12 healthy elderly (50 to 92 years; 8 m and 4… CONTINUE READING

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