Effect of age and gender on pharmacokinetics and pharmacodynamics of a single ticagrelor dose in healthy individuals

Abstract

The aim of this study was to assess age and gender effects on ticagrelor pharmacokinetics and pharmacodynamics (PK/PD). Forty healthy individuals [18–45 years (young); ≥65 years (elderly); ten men, ten women per age group) received 200 mg ticagrelor. Ticagrelor was rapidly absorbed [time to maximum concentration (Cmax) (tmax) 2.5–3.0 h], and its major… (More)
DOI: 10.1007/s00228-012-1227-4

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