Effect of age and cinnarizine treatment on brain dopamine receptors.

  title={Effect of age and cinnarizine treatment on brain dopamine receptors.},
  author={Montserrat Camps and Santiago Ambrosio and Julia Reiriz and M. Ballarin and Blanca Cutillas and Nicole Mahy},
  volume={46 1},
The density and distribution of dopamine D1 and D2 receptors visualized by in vitro autoradiography were investigated in adult and senescent BL C57 mice. A significant decrease was observed in regions of the basal ganglia of senescent animals, which was more pronounced for the D1 subtype. Chronic treatment with cinnarizine, an organic Ca2+ channel antagonist, alters both D1 and D2 receptor densities, with a higher sensitivity of the D1 subtype. These results could indicate that the interactions… 
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