Effect of age, ethnicity, and head injury on the association between APOE genotypes and Alzheimer's disease.

@article{Tang1996EffectOA,
  title={Effect of age, ethnicity, and head injury on the association between APOE genotypes and Alzheimer's disease.},
  author={M. X. Tang and Gladys Maestre and Wei Yann Tsai and X. H. Liu and Lin Feng and Woung Youn Chung and M Chun and Peter Schofield and Yaakov Stern and Benjamin Tycko and Richard P. Mayeux},
  journal={Annals of the New York Academy of Sciences},
  year={1996},
  volume={802},
  pages={6-15}
}
The association between apolipoprotein E (APOE)-epsilon 4 and Alzheimer's disease has been confirmed worldwide. We and others have observed a diminished association in the very old and among African-Americans compared to Caucasians and Hispanics in New York. In this review we describe a new method we developed to compare relative risks by APOE genotypes in an expanded cohort of cases and controls from three ethnic groups in a New York City community and discuss the association as between APOE… CONTINUE READING

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Alzheimer's DiseaseAssociated with malfunction of gene productApolipoprotein E
The association between apolipoprotein E ( APOE)-epsilon 4 and Alzheimer 's disease has been confirmed worldwide .
Compared to persons with APOE epsilon 3/epsilon 3 genotypes , relative risk ( RR ) for Alzheimer 's disease associated with APOE epsilon 4 homozygosity was similar across ethnic groups ( African - American RR = 3.3 ; 95% c.i .
Compared to persons with APOE epsilon 3/epsilon 3 genotypes , relative risk ( RR ) for Alzheimer 's disease associated with APOE epsilon 4 homozygosity was similar across ethnic groups ( African - American RR = 3.3 ; 95% c.i .
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