Effect of aerosolized colistin as adjunctive treatment on the outcomes of microbiologically documented ventilator-associated pneumonia caused by colistin-only susceptible gram-negative bacteria.

@article{Tumbarello2013EffectOA,
  title={Effect of aerosolized colistin as adjunctive treatment on the outcomes of microbiologically documented ventilator-associated pneumonia caused by colistin-only susceptible gram-negative bacteria.},
  author={Mario Tumbarello and Gennaro De Pascale and Enrico Maria Trecarichi and Salvatore De Martino and Giuseppe Lo Bello and Riccardo Maviglia and Teresa Spanu and Massimo Antonelli},
  journal={Chest},
  year={2013},
  volume={144 6},
  pages={1768-1775}
}
BACKGROUND The increasing frequency of ventilator-associated pneumonia (VAP) caused by colistin-only susceptible (COS) gram-negative bacteria (GNB) is of great concern. Adjunctive aerosolized (AS) colistin can reportedly increase alveolar levels of the drug without increasing systemic toxicity. Good clinical results have been obtained in patients with… CONTINUE READING