Effect of aerobic exercise training on mtDNA deletion in soleus muscle of trained and untrained Wistar rats.


BACKGROUND According to the theory of mitochondrial aging, oxidative stress plays a major role in aging and age related degenerative diseases. Since oxygen consumption and reactive oxygen species rate increase during aerobic exercise, we hypothesised that heavy aerobic training could lead to enhanced mitochondrial DNA (mtDNA) deletion in postmitotic tissues… (More)


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