Effect of adrenalectomy and cortisone administration on components of the liver microsomal mixed function oxygenase system of male rats which catalyzes ethylmorphine metabolism.

@article{Castro1970EffectOA,
  title={Effect of adrenalectomy and cortisone administration on components of the liver microsomal mixed function oxygenase system of male rats which catalyzes ethylmorphine metabolism.},
  author={Jos{\'e} Alberto de Castro and Frank E. Greene and Philippe Gigon and Henry A. Sasame and James R. Gillette},
  journal={Biochemical pharmacology},
  year={1970},
  volume={19 8},
  pages={
          2461-7
        }
}
Effects of cortisol administration on components of the hepatic microsomal mixed function oxidase system (MFO) of immature rainbow trout (Salmo gairdnerii Rich.).
TLDR
The cortisol-treated fish lost considerably more body weight than corresponding controls during the experimental period, while the effects on liver wet weight and liver somatic index were inconclusive.
Oxidative drug metabolism in liver microsomes from uremic rats.
TLDR
There was a pronounced decrease in the specific activity of liver microsomes from uremic rats for the demethylation of aminopyrine and p-nitroanisole and for the p-hydroxylation of acetanilide in comparison with sham-operated controls, which is assumed to be due to reduced cytochrome P-450 content.
Vitamin E , steroids , and liver 966
TLDR
The effectiveness of phenobarbital as an inducer was found to depend in part on the androgen status of the animals but part of the effect was independent of this factor.
...
...

References

SHOWING 1-10 OF 14 REFERENCES
Sex differences in the effects of abnormal physiological states on the metabolism of drugs by rat liver microsomes.
  • R. Kato, J. Gillette
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1965
TLDR
The findings suggest that the various treatments impair mainly the sex-dependent enzymes in liver microsomes, and alloxan and thyroxine in female rats enhance the metabolism of aminopyrine, aniline, and zoxazolamine by livermicrosomes.
EFFECT OF STARVATION ON NADPH-DEPENDENT ENZYMES IN LIVER MICROSOMES OF MALE AND FEMALE RATS
TLDR
Although liver microsomes from male rats metabolize most drugs more rapidly than do those from female rats, the magnitude of the sex difference varies markedly with the substrate and the effects of starvation of male rats range from impairment of sex-dependent enzymes which metabolize aminopyrine and hexobarbital to enhancement of thesex-independent enzyme that hydroxylates aniline.
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.
TLDR
The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
ENDOCRINE MODIFICATION OF DRUG RESPONSES IN THE RAT.
TLDR
It is suggested that the pituitary-adrenal axis serves a regulatory function with respect to duration of drug responses which may be mediated by an alteration of drug metabolism.
SIMILARITIES BETWEEN OXIDATIVE DRUG-METABOLIZING ENZYMES AND STEROID HYDROXYLASES IN LIVER MICROSOMES.
TLDR
Liver microsomal enzymes oxidatively metabolize steroids and foreign compounds in the presence of TPNH and oxygen to compounds which are more polar than the substrate suggest that steroid hormones are normally occurring substrates for oxidative drug-metabolizing enzymes in liver microsomes.
...
...