Effect of adenovirus-mediated heat shock protein expression and oncolysis in combination with low-dose cyclophosphamide treatment on antitumor immune responses.

@article{Paolo2006EffectOA,
  title={Effect of adenovirus-mediated heat shock protein expression and oncolysis in combination with low-dose cyclophosphamide treatment on antitumor immune responses.},
  author={Nelson C. Di Paolo and Sebastian Tuve and Shaoheng Ni and Karl Erik Hellstr{\"o}m and Ingegerd Hellstr{\"o}m and Andr{\'e} Lieber},
  journal={Cancer research},
  year={2006},
  volume={66 2},
  pages={960-9}
}
Heat shock proteins such as gp96 have the ability to chaperone peptides and activate antigen-presenting cells. In this study, we tested whether adenovirus-mediated overexpression of secreted or membrane-associated forms of gp96 in tumor cells would stimulate an antitumor immune response. Studies were carried out in C57Bl/6 mice bearing aggressively growing… CONTINUE READING