• Corpus ID: 53286168

Effect of adding medical cannabis to analgesic treatment in patients with low back pain related to fibromyalgia: an observational cross-over single centre study.

@article{Yassin2019EffectOA,
  title={Effect of adding medical cannabis to analgesic treatment in patients with low back pain related to fibromyalgia: an observational cross-over single centre study.},
  author={Mustafa Eltigani Yassin and Amir Oron and Dror Robinson},
  journal={Clinical and experimental rheumatology},
  year={2019},
  volume={37 Suppl 116 1},
  pages={
          13-20
        }
}
OBJECTIVES Low back pain (LBP) occurs in many patients with fibromyalgia (FM). The current study aimed to assess the possible pain and function amelioration associated with medical cannabis therapy (MCT) in this setting. METHODS 31 patients were involved in an observational cross-over study. The patients were screened, treated with 3 months of standardised analgesic therapy (SAT): 5 mg of oxycodone hydrochloride equivalent to 4.5 mg oxycodone and 2.5 mg naloxone hydrochloride twice a day and… 

Figures and Tables from this paper

Adding medical cannabis to standard analgesic treatment for fibromyalgia: a prospective observational study.

This observational study shows that adjunctive MCT offers a possible clinical advantage in FM patients, especially in those with sleep dysfunctions, and the clinical improvement inversely correlated with BMI.

Comparing Sublingual and Inhaled Cannabis Therapies for Low Back Pain: An Observational Open-Label Study

The findings indicate that inhaled THC-rich therapy is more effective than CBD-rich sublingual extract therapy for treating low back pain and that cannabis therapy is safe and effective for chronic low backPain.

Can Medical Cannabis Therapies be Cost-Effective in the Non-Surgical Management of Chronic Knee Pain?

The study showed that MC may be a cost-effective strategy in the management of chronic knee pain; however, the evidence on the medical use of cannabis is limited and predominantly low-quality.

EXPLORING THE EFFICACY AND SAFETY OF CANNABIS IN THE MANAGEMENT OF FIBROMYALGIA

There is insufficient evidence to prescribe the currently available licensed medicines or to recommend the complementary health products available for legal purchase, and there is a need for more global clinical randomised trials to accurately determine medicinal cannabis short and long-term long efficacy and safety.

The Effect of Medical Cannabis on Pain Level and Quality of Sleep among Rheumatology Clinic Outpatients

MC had a favorable effect on pain level and quality of sleep among all spectrums of problems at the rheumatology clinic.

Opioid-sparing effects of medical cannabis or cannabinoids for chronic pain: a systematic review and meta-analysis of randomised and observational studies

Opioid-sparing effects of medical cannabis for chronic pain remain uncertain due to very low certainty evidence.

A review of studies evaluating medical cannabis for the chronic pain management

Evidence suggests that cannabis-based medicine can be safe and effective in pain relief and recommends optimal doses, routes of administration and used types of cannabinoids for establishment of prospective recommendations and guidelines.

Cannabis-Based Medicines and Medical Cannabis in the Treatment of Nociplastic Pain

The understanding of nociplastic pain is explained, the evidence for the effect of cannabinoids in these conditions is examined, and simplified guidance is provided for healthcare providers who may consider prescribing cannabinoids for these conditions.

Cannabinoids for fibromyalgia pain: a critical review of recent studies (2015–2019)

Although the critically reviewed studies superficially suggest that medical cannabis is a safe and effective treatment for fibromyalgia pain, serious methodological limitations prevent a definitive conclusion regarding the use of cannabinoids for pain management in Fibromyalgia patients at this time.

Efficacy of cannabinoids in fibromyalgia: a literature review

The use of cannabis seems to be beneficial in patients with fibromyalgia; however, more robust studies are still needed to establish is actual efficacy in pain management, quality of life and improvement of associated symptoms.

References

SHOWING 1-10 OF 33 REFERENCES

Effect of Medicinal Cannabis Therapy (MCT) on Severity of Chronic Low BackPain, Sciatica and Lumbar Range of Motion

Short term usage of smoked medicinal cannabis appear to improve both physical and mental function while decreasing pain levels of chronic low back pain sufferers.

Clinical experience with duloxetine in the management of chronic musculoskeletal pain. A focus on osteoarthritis of the knee

This review concludes that duloxetine is safe and effective when used adjunctively with nonsteroidal anti-inflammatory drugs, and that there are no new safety signals beyond what has been observed in other indications.

Efficacy and Safety of Duloxetine in Patients With Chronic Low Back Pain

Duloxetine significantly reduced pain and improved functioning in patients with CLBP and the safety and tolerability were similar to those reported in earlier studies.

A randomized, double-blind, placebo-controlled phase III trial of duloxetine in Japanese fibromyalgia patients

Duloxetine treatment was associated with improved outcomes in secondary and post hoc analyses of the mean change in the BPI average pain score and most of the secondary outcomes, including analgesia and QoL.

Efficacy of Duloxetine in Patients with Chronic Pain Conditions

The analyses reported here show that duloxetine is efficacious in treating chronic pain as demonstrated by significant improvement in pain intensity, physical functioning, and patient ratings of overall improvement.

Quality of Life and Healthcare Resource in Patients Receiving Opioids for Chronic Pain: A Review of the Place of Oxycodone/Naloxone

In patients with moderate-to-severe chronic pain, randomized trials have demonstrated that OXN PR has equal analgesic efficacy and safety, but results in improved bowel function, compared with prolonged-release oxycodone (Oxy PR) alone.

Prevalence and Treatment Outcome of Primary and Secondary Fibromyalgia in Patients With Spinal Pain

Fibromyalgia is a disorder that occurs in a small proportion of patients with back pain and in the authors' limited experience, patients with primary fibromyalgia appear to improve with conservative care.

An open-label, long-term, phase III extension trial of duloxetine in Japanese patients with fibromyalgia

Duloxetine was safe and effective in the long-term treatment of Japanese patients with fibromyalgia and the Brief Pain Inventory average pain score improved at all time-points compared with baseline.

What is the evidence that neuropathic pain is present in chronic low back pain and soft tissue syndromes? An evidence-based structured review.

There is consistent evidence by all methods that NP is present in CLBP and STS.

Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials.

There is evidence that cannabinoids are safe and modestly effective in neuropathic pain with preliminary evidence of efficacy in fibromyalgia and rheumatoid arthritis and the context of the need for additional treatments for chronic pain is reviewed.