Effect of adaptation to moderate physical loads on the increased resistance of the isolated heart to ischemia and reperfusion

@article{Malyshev2006EffectOA,
  title={Effect of adaptation to moderate physical loads on the increased resistance of the isolated heart to ischemia and reperfusion},
  author={I. Yu. Malyshev and P. A. Prodius and Felix Z. Meerson},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2006},
  volume={119},
  pages={20-22}
}
Adaptation to physical loads elicits pronounced anti-ischemic and antireperfusion effects on the isolated heart. By the 20th min of total ischemia contracture in the hearts of adapted animals is much less than that in the control group. During reperfusion of hearts from adapted animals the degree of restoration of the contractile force was 6-fold higher, contracture was lesser, and the total period of tachycardia and fibrillation were 3-fold shorter than in the control. 

Increased resistance to heat shock of isolated hearts from rats adapted to moderate physical exercise

Hearts isolated from rats adapted to physical activity through moderate regular exercise (swimming) were more resistant to heat shock than hearts from unadapted controls and caused a contracture amounting to 36% of the initial contraction amplitude, as well as increased release of creatine kinase into the perfusate.

Blocked production of thermal shock proteins prevents the cardioprotective effect of adaptation to exercise

The resistance of isolated rat heart to ischemia and reperfusion increases after adaptation to exercise, which correlated with accumulation of HSP70 cytoprotector proteins in the myocardium, which was hypothesized to be an important mechanism of local adaptation defense of the heart.

Adaptation to physical exercise increases expression of Ca-ATPase gene in myocardial sarcoplasmic reticulum

The adaptation-induced increase in the power of the sarcoplasmic reticulum Ca2+-pump can be attributed to activated synthesis and accumulation of SERCA-2a isoform.

ECG Research Using Elements of Matrix Analysis and Phase Planes

Electrocardiogram (ECG) is a diagnostic tool that measures activity of the heart. The dynamics of coherence between two different ECG parameters is investigated. Two time series, representing RR and

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