Effect of adaptation to moderate physical loads on the increased resistance of the isolated heart to ischemia and reperfusion

  title={Effect of adaptation to moderate physical loads on the increased resistance of the isolated heart to ischemia and reperfusion},
  author={I. Yu. Malyshev and P. A. Prodius and Felix Z. Meerson},
  journal={Bulletin of Experimental Biology and Medicine},
Adaptation to physical loads elicits pronounced anti-ischemic and antireperfusion effects on the isolated heart. By the 20th min of total ischemia contracture in the hearts of adapted animals is much less than that in the control group. During reperfusion of hearts from adapted animals the degree of restoration of the contractile force was 6-fold higher, contracture was lesser, and the total period of tachycardia and fibrillation were 3-fold shorter than in the control. 

Increased resistance to heat shock of isolated hearts from rats adapted to moderate physical exercise

Hearts isolated from rats adapted to physical activity through moderate regular exercise (swimming) were more resistant to heat shock than hearts from unadapted controls and caused a contracture amounting to 36% of the initial contraction amplitude, as well as increased release of creatine kinase into the perfusate.

Blocked production of thermal shock proteins prevents the cardioprotective effect of adaptation to exercise

The resistance of isolated rat heart to ischemia and reperfusion increases after adaptation to exercise, which correlated with accumulation of HSP70 cytoprotector proteins in the myocardium, which was hypothesized to be an important mechanism of local adaptation defense of the heart.

Adaptation to physical exercise increases expression of Ca-ATPase gene in myocardial sarcoplasmic reticulum

The adaptation-induced increase in the power of the sarcoplasmic reticulum Ca2+-pump can be attributed to activated synthesis and accumulation of SERCA-2a isoform.

ECG Research Using Elements of Matrix Analysis and Phase Planes

Electrocardiogram (ECG) is a diagnostic tool that measures activity of the heart. The dynamics of coherence between two different ECG parameters is investigated. Two time series, representing RR and



Physical Training Increases Ventricular Fibrillation Thresholds of Isolated Rat Hearts During Normoxia, Hypoxia and Regional Ischemia

It is concluded that running training increases the resistance of the heart to ventricular fibrillation by mechanisms that are largely unknown, although they may involve cyclic AMP.

Effect of physical training on coronary collateral circulation of the rat.

  • J. KoernerR. Terjung
  • Biology, Medicine
    Journal of applied physiology: respiratory, environmental and exercise physiology
  • 1982
Results indicate that training caused a limited increase in collateral blood flow to the border zone, which could lead to an improved salvage of tissue in sedentary rats.

Training-induced changes in hormonal and metabolic responses to submaximal exercise.

The hormonal component of the training adaptation occurs very early in the course of a vigorous endurance training program, particularly in endurance-trained individuals and in untrained subjects.

Differences in the metabolic and hormonal response to exercise between racing cyclists and untrained individuals.

It is concluded that there are significant differences in the metabolic and hormonal responses to exercise between athletically trained and untrained individuals, even when the physically fit subjects work at the same percentage of their maximal capacity as the unfit subjects.

Dynamics of formation and reversion of the phenomenon of adaptational stabilization of structures correlates with changes in HSP70 content in the myocardium

PASS has been found to be realized against the background of a considerably increased content of heat-shock proteins (hsp70) in the myocardium, together with alterations in their isoform composition and subceUular distribution.

Effects of physical exercise and/or vitamin E on tissue oxidative metabolism.

Lateral diffusion of the redox components is sufficiently rapid for electron transport in the mitrochondrial inner membrane to be diffusion-controlled and is consistent with a 'random-collision model' of electron transportIn the mitochondrial inner membrane.

Effects of exercise and conditioning on rat heart glycogen and glycogen synthase.

  • L. D. SegelD. Mason
  • Biology
    Journal of applied physiology: respiratory, environmental and exercise physiology
  • 1978

Adaptation to Stress Situations and Physical Loads [in Russian

  • Theory and Practice of Physical Culture,
  • 1985