Effect of acute tryptophan depletion on CO2-induced anxiety in patients with panic disorder and normal volunteers.

@article{Miller2000EffectOA,
  title={Effect of acute tryptophan depletion on CO2-induced anxiety in patients with panic disorder and normal volunteers.},
  author={Heather J Miller and J F William Deakin and Ian Muir Anderson},
  journal={The British journal of psychiatry : the journal of mental science},
  year={2000},
  volume={176},
  pages={
          182-8
        }
}
BACKGROUND Uncertainties remain about the role of serotonin in the aetiology and treatment of panic disorder. AIMS To investigate the effect of reducing brain serotonin function on anxiety at rest, and following 5% CO2 provocation in normal controls and patients with panic disorder. METHOD Twenty drug-free patients with DSM-III-R panic disorder and 19 controls received a tryptophan-free amino acid drink on one occasion and a control drink on the other in a double-blind, balanced protocol. 5… CONTINUE READING

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