Effect of acute spinal cord injury on axonal counts in the pyramidal tract of rats.
@article{Tator1984EffectOA,
title={Effect of acute spinal cord injury on axonal counts in the pyramidal tract of rats.},
author={Charles Tator and Andrea Rivlin and Andrew J Lewis and Birgit Schmoll},
journal={Journal of neurosurgery},
year={1984},
volume={61 1},
pages={
118-23
}
}The concentration of axons in the pyramidal tract of normal and spinal cord-injured rats was determined by counting axons in sections of spinal cord stained by the Holmes technique. In the normal rat the axon concentration was uniform in the cervical, thoracic, and lumbar regions, although the size of the tract diminished progressively with its descent in the cord. After acute cord transection or compression injury, the axon concentration distal to the injury site diminished markedly. However…Â
22 Citations
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No relation was found between degree of function as tested by inclined plane and extent of morphologic injury in individual animals, and the time course of the cell changes in the cord at the site of and distal to the compression was studied.
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OBJECT
There is a need for an accurate quantitative histological technique that also provides information on neurons, axons, vascular endothelium, and subcellular organelles after spinal cord injury…
Experimental spinal cord injury: qualitative and quantitative histopathologic evaluation.
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A "volumetric" assessment of the total region of injury is recommended as preferable to a histopathologic evaluation limited to the epicenter, reflecting volume of residual tissue in the longitudinal extent of injury, showed greater statistical correlation with functional (behavioral) outcome.
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