Effect of acute severe hypoxia on peripheral fatigue and endurance capacity in healthy humans.

@article{Romer2007EffectOA,
  title={Effect of acute severe hypoxia on peripheral fatigue and endurance capacity in healthy humans.},
  author={Lee M Romer and Hans Christian Haverkamp and Markus Amann and Andrew T. Lovering and David F. Pegelow and Jerome A. Dempsey},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2007},
  volume={292 1},
  pages={R598-606}
}
We hypothesized that severe hypoxia limits exercise performance via decreased contractility of limb locomotor muscles. Nine male subjects [mean +/- SE maximum O(2) uptake (Vo(2 max)) = 56.5 +/- 2.7 ml x kg(-1) x min(-1)] cycled at > or =90% Vo(2 max) to exhaustion in normoxia [NORM-EXH; inspired O(2) fraction (Fi(O(2))) = 0.21, arterial O(2) saturation (Sp(O(2))) = 93 +/- 1%] and hypoxia (HYPOX-EXH; Fi(O(2)) = 0.13, Sp(O(2)) = 76 +/- 1%). The subjects also exercised in normoxia for a time equal… CONTINUE READING