Effect of acute lung injury on structure and function of pulmonary surfactant films.

  title={Effect of acute lung injury on structure and function of pulmonary surfactant films.},
  author={Amiya Kumar Panda and K Harish Nag and Robert R. Harbottle and Karina Rodr{\'i}guez-Capote and Ruud A. W. Veldhuizen and Nils O. Petersen and Fred Possmayer},
  journal={American journal of respiratory cell and molecular biology},
  volume={30 5},
The structural and functional alterations in pulmonary surfactant that occur during acute lung injury were studied using rat lung surfactant large aggregates (LA) isolated from normal nonventilated lungs (N), and from standard ventilated (V) and injuriously ventilated (IV) excised lungs. N lungs inflated significantly better than IV lungs, with V lungs intermediate. Although IV LA phosphatidylcholine levels were unchanged, cholesterol and protein were elevated. V LA exhibited PC/cholesterol and… CONTINUE READING


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