Effect of acute hyperglycaemia and diabetes mellitus with and without short-term insulin treatment on myocardial ischaemic late preconditioning in the rabbit heart in vivo

@article{Ebel2003EffectOA,
  title={Effect of acute hyperglycaemia and diabetes mellitus with and without short-term insulin treatment on myocardial ischaemic late preconditioning in the rabbit heart in vivo},
  author={Dirk Ebel and Jost M{\"u}llenheim and Jan Fraessdorf and Andr{\'e} P. Heinen and Ragnar Huhn and T. Bohlen and Jan Ferrari and Hendrik S{\"u}dkamp and Benedikt Preckel and Wolfgang Schlack and Volker Th{\"a}mer},
  journal={Pfl{\"u}gers Archiv},
  year={2003},
  volume={446},
  pages={175-182}
}
Diabetes mellitus (DM) and the resulting hyperglycaemia may interfere with the cardioprotective effect of ischaemic late preconditioning (LPC). Therefore, we investigated the effect of acute hyperglycaemia (part 1) and the effect of alloxan-induced DM with or without short-term insulin treatment (part 2) on LPC. Rabbits, chronically instrumented with a coronary artery occluder, were subjected to 30 min coronary artery occlusion and 2 h reperfusion (I/R) and infarct size (IS) was assessed. In… CONTINUE READING
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