Effect of acute global ischemia on the upper limit of vulnerability: a simulation study.

@article{Rodriguez2004EffectOA,
  title={Effect of acute global ischemia on the upper limit of vulnerability: a simulation study.},
  author={Blanca E. Rodriguez and Brock M Tice and James Eason and Felipe Aguel and Jos{\'e} M. Ferrero and Natalia A. Trayanova},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2004},
  volume={286 6},
  pages={H2078-88}
}
The goal of this modeling research is to provide mechanistic insight into the effect of altered membrane kinetics associated with 5-12 min of acute global ischemia on the upper limit of cardiac vulnerability (ULV) to electric shocks. We simulate electrical activity in a finite-element bidomain model of a 4-mm-thick slice through the canine ventricles that incorporates realistic geometry and fiber architecture. Global acute ischemia is represented by changes in membrane dynamics due to… CONTINUE READING