Effect of acute exercise on uncoupling protein 3 is a fat metabolism-mediated effect.

@article{Schrauwen2002EffectOA,
  title={Effect of acute exercise on uncoupling protein 3 is a fat metabolism-mediated effect.},
  author={Patrick Schrauwen and Matthijs K. C. Hesselink and Ilonca Vaartjes and Esther Kornips and Wim H. M. Saris and Jean Paul Giacobino and Aaron P. Russell},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2002},
  volume={282 1},
  pages={
          E11-7
        }
}
Human and rodent uncoupling protein (UCP)3 mRNA is upregulated after acute exercise. Moreover, exercise increases plasma levels of free fatty acid (FFA), which are also known to upregulate UCP3. We investigated whether the upregulation of UCP3 after exercise is an effect of exercise per se or an effect of FFA levels or substrate oxidation. Seven healthy untrained men [age: 22.7 +/- 0.6 yr; body mass index: 23.8 +/- 1.0 kg/m(2); maximal O2 uptake (VO2 max): 3,852 +/- 211 ml/min] exercised at 50… 

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References

SHOWING 1-10 OF 37 REFERENCES
Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans.
TLDR
The similar induction of gene expression observed during fasting in lean and obese subjects shows that there is no major alteration of UCP2 and -3 gene regulation in adipose tissue and skeletal muscle of obese subjects and suggests a role for these proteins in the metabolic adaptation to fasting.
Elevated Free Fatty Acids Induce Uncoupling Protein 3 Expression in Muscle: A Potential Explanation for the Effect of Fasting
TLDR
It is concluded that free fatty acids are a potential mediator of the increase in muscle UCP3 expression that occurs during fasting, and may be linked to the use of free fatty acid as a fuel rather than an increased need of the organism to dissipate energy.
Regulation of uncoupling protein-2 and uncoupling protein-3 mRNA expression during lipid infusion in human skeletal muscle and subcutaneous adipose tissue.
TLDR
It is concluded that increased plasma NEFA levels by lipid infusion for 5 h induces the expression of UCP-3 but not U CP-2 in humans.
Skeletal muscle uncoupling protein 3 expression is a determinant of energy expenditure in Pima Indians.
TLDR
Results indicate that UCP-3 may be a determinant of energy expenditure and metabolic efficiency in Pima Indians.
UCP-3 expression in skeletal muscle: effects of exercise, hypoxia, and AMP-activated protein kinase.
TLDR
It is shown that treadmill running by rats rapidly induces skeletal muscle UCP-3 mRNA expression, as do hypoxia and swimming in a comparably rapid and substantial fashion, consistent with the notion that activation of AMPK, presumably as a result of fuel depletion, rapidly regulates U CP-3 gene expression.
Fatty acid oxidation is directly regulated by carbohydrate metabolism during exercise.
TLDR
Sub substrate oxidation during exercise can be regulated by increased glycolytic flux that is accompanied by a direct inhibition of long-chain fatty acid oxidation, as indicated by a coordination of effects on adipose tissue and muscle.
Regulation of skeletal muscle UCP-2 and UCP-3 gene expression by exercise and denervation.
TLDR
The results indicate that acute exercise and denervation regulate gene expression of skeletal muscle UCPs and no changes in either UCP-2 or U CP-3 mRNA levels after chronic exercise.
Human uncoupling proteins and obesity.
Uncoupling protein (UCP) 2 and UCP3 are newly discovered proteins that can uncouple ATP production from mitochondrial respiration, thereby dissipating energy as heat and affecting energy metabolism
Up-regulation of uncoupling protein 3 (UCP3) mRNA by exercise training and down-regulation of UCP3 by denervation in skeletal muscles.
TLDR
The data indicate that UCP3 may have a role for fine adjustments of energy expenditure and that up-regulation of U CP3 mRNA may be a defense mechanism against extra energy supply to consume extra energy in skeletal muscles.
Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
TLDR
Evidence is provided that skeletal muscle UCP-3 has the potential to influence metabolic rate and glucose homeostasis in the whole animal by the creation of transgenic mice that overexpress human U CP-3 in skeletal muscle.
...
1
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4
...