Effect of acute elevation of IGF-I on circulating GH, TSH, insulin, IGF-II and IGFBP-3 levels in non-endocrine short stature (NESS)

@article{Hanew2001EffectOA,
  title={Effect of acute elevation of IGF-I on circulating GH, TSH, insulin, IGF-II and IGFBP-3 levels in non-endocrine short stature (NESS)},
  author={Kunihiko Hanew and Atsushi Tanaka},
  journal={Journal of Endocrinological Investigation},
  year={2001},
  volume={24},
  pages={1-7}
}
It is not clear whether acute and slight elevation of serum IGF-I, which does not affect blood glucose levels, modulates circulating GH levels. To clarify this, small doses of recombinant human IGF-I (rhIGF-I, 5 μg/kg, iv) were administered as a bolus to 10 children with non-endocrine short stature (NESS) (5 males and 5 females, 11.2±0.7 yr old) after an overnight fast. Physiological saline was administered intravenously to sex- and age-matched NESS controls (5 males and 5 females, 10.9±0.7 yr… CONTINUE READING

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