Effect of acute antidepressant administration on negative affective bias in depressed patients.

  title={Effect of acute antidepressant administration on negative affective bias in depressed patients.},
  author={Catherine J. Harmer and Ursula D. O'Sullivan and Elisa Favaron and Rachel Massey-Chase and Rachael Ayres and Andrea Reinecke and Guy M. Goodwin and Philip J. Cowen},
  journal={The American journal of psychiatry},
  volume={166 10},
OBJECTIVE Acute administration of an antidepressant increases positive affective processing in healthy volunteers, an effect that may be relevant to the therapeutic actions of these medications. The authors investigated whether this effect is apparent in depressed patients early in treatment, prior to changes in mood and symptoms. METHOD In a double-blind, placebo-controlled, between-groups randomized design, the authors examined the effect of a single 4-mg dose of the norepinephrine reuptake… CONTINUE READING
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