Effect of acute and repeated exposure to low doses of hydrazine on hepatic microsomal enzymes and biochemical parameters in vivo

@article{Jenner1994EffectOA,
  title={Effect of acute and repeated exposure to low doses of hydrazine on hepatic microsomal enzymes and biochemical parameters in vivo},
  author={Andrew M. Jenner and John A. Timbrell},
  journal={Archives of Toxicology},
  year={1994},
  volume={68},
  pages={240-245}
}
A single dose of hydrazine (3 mg·kg−1 i.p.) caused hepatic accumulation of triglycerides and depletion of ATP in rats after 9 h. Repeated exposure of rats to hydrazine (≊2.5 mg·kg−1 per day) for 10 days resulted in depletion of hepatic reduced glutathione (GSH) and triglycerides. Repeated exposure to hydrazine also caused a significant (time dependent) induction ofp-nitrophenol hydroxylase (NPH) activity together with changes in other hepatic microsomal enzymes. These included 7… CONTINUE READING

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