Effect of acute and prolonged mineralocorticoid receptor blockade on spontaneous and stimulated hypothalamic-pituitary-adrenal axis in humans.

@article{Berardelli2010EffectOA,
  title={Effect of acute and prolonged mineralocorticoid receptor blockade on spontaneous and stimulated hypothalamic-pituitary-adrenal axis in humans.},
  author={Rita Berardelli and Ioannis Karamouzis and Elisa Marinazzo and Elisa Prats and Andreea Maria Picu and Roberta Giordano and Ezio Ghigo and Emanuela Arvat},
  journal={European journal of endocrinology},
  year={2010},
  volume={162 6},
  pages={1067-74}
}
CONTEXT Mineralocorticoid receptors (MRs) in the hippocampus display an important role in the control of the hypothalamic-pituitary-adrenal (HPA) axis, mediating the proactive feedback of glucocorticoids, which maintains the basal HPA activity. The systemic administration of MR antagonists enhances spontaneous and CRH-stimulated ACTH, cortisol, and DHEA secretion, while the effects of chronic treatment with MR antagonists are scanty. Our study was performed in order to clarify this point… CONTINUE READING

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Mineralocorticoid receptor-mediated inhibition of the hypothalamic-pituitary-adrenal axis in aged humans.

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