Effect of acute and chronic treatment of tandamine, a new heterocyclic antidepressant, on biogenic amine metabolism and related activities

@article{Pugsley2004EffectOA,
  title={Effect of acute and chronic treatment of tandamine, a new heterocyclic antidepressant, on biogenic amine metabolism and related activities},
  author={Thomas A. Pugsley and Wilbur Lippmann},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={308},
  pages={239-247}
}
  • T. Pugsley, W. Lippmann
  • Published 1 September 1979
  • Biology, Psychology, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
SummaryThe effects of tandamine, a clinically effective heterocyclic antidepressant, administered either acutely (10 mg/kg i.p) or chronically (10 mg/kg i.p. daily for 21 days) on biogenic amine uptake and metabolism in the rat were determined and a comparison with desipramine was made. Tandamine, similarly to desipramine, blocked norepinephrine (NE) uptake in rat brain and heart following both acute and chronic administration. No effect of tandamine on dopamine (DA) or serotonin (5-HT) uptake… 

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