Effect of acute and chronic calcium administration on plasma renin.

@article{Kotchen1974EffectOA,
  title={Effect of acute and chronic calcium administration on plasma renin.},
  author={Theodore Kotchen and K I Mauli and Robert Luke and David Rees and Walter Flamenbaum},
  journal={The Journal of clinical investigation},
  year={1974},
  volume={54 6},
  pages={1279-86}
}
To evaluate the effect of Ca(++) on renin release, plasma renin activity (PRA) was measured after acute and chronic Ca(++) administration. 1% CaCl(2) was infused into one renal artery of 10 anesthetized dogs (0.3 mg/kg/min). The excreted fraction of filtered calcium (EF(ca++)) and EF(Na+) from the infused kidney were elevated (P < 0.04) during three successive 15-min infusion periods. Serum calcium concentration was significantly elevated (P < 0.001). Creatinine clearance, systemic arterial… CONTINUE READING

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