Effect of active transport on distribution and concentration gradients of [3H]benzylpenicillin in the cerebrospinal fluid.

@article{Striki1994EffectOA,
  title={Effect of active transport on distribution and concentration gradients of [3H]benzylpenicillin in the cerebrospinal fluid.},
  author={N Striki{\'c} and Marijan Klarica and Anton Vladi{\'c} and Marin Bulat},
  journal={Neuroscience letters},
  year={1994},
  volume={169 1-2},
  pages={159-62}
}
After application of [3H]benzylpenicillin ([3H]BP) in lateral brain ventricle in dogs, the distribution of [3H]BP to contralateral ventricle and cisterna magna was much higher when its active transport from cerebrospinal fluid (CSF) was blocked by probenecid than under control conditions. Analysis of [3H]BP concentrations in both lateral ventricles and cisterna magna over time indicates that active transport restricts distribution of substances along CSF spaces and contributes to the… CONTINUE READING