Effect of active site-inactivated factor VIIa on ischaemia/reperfusion injury in a porcine flap model.

@article{Sderstrm2004EffectOA,
  title={Effect of active site-inactivated factor VIIa on ischaemia/reperfusion injury in a porcine flap model.},
  author={Torbj{\"o}rn S{\"o}derstr{\"o}m and Lene Birk-S\orensen and Henrik Holst-Jensen and Ulla Hedner and Bj{\"o}rn Arnljots},
  journal={Scandinavian journal of plastic and reconstructive surgery and hand surgery},
  year={2004},
  volume={38 6},
  pages={326-34}
}
In free flap surgery, restored blood flow following a lengthy ischaemic period may lead to necrosis as a result of ischaemia/reperfusion (IR) injury. This injury comprises both proinflammatory and prothrombotic events, where the tissue factor/factor VIIa complex probably has a key role. Active site-inactivated factor VIIa (FFR-rFVIIa) exerts an antithrombotic effect by binding to tissue factor without initiating coagulation. In this study we have evaluated the potential protective effects of… CONTINUE READING

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