Effect of actinomycin D on uterine prostaglandin production and oestrous cycle length in guinea-pigs.

@article{Poyser1979EffectOA,
  title={Effect of actinomycin D on uterine prostaglandin production and oestrous cycle length in guinea-pigs.},
  author={N. L. Poyser},
  journal={Journal of reproduction and fertility},
  year={1979},
  volume={56 2},
  pages={559-65}
}
  • N. L. Poyser
  • Published 1979 in Journal of reproduction and fertility
Intrauterine, but not systemic, administration of actinomycin D on Day 10 increased oestrous cycle length in guinea-pigs. Peripheral plasma progesterone levels remained elevated during these lengthened cycles presumably because luteal life-span had been extended. Prostaglandin (PG) F-2 alpha production in vitro, on Day 15, by the uterus of guinea-pigs which had received intrauterine actinomycin D was much lower than control values. This decrease in PG production was not due to lack of precursor… CONTINUE READING