Effect of acoustic conditions on microbubble-mediated microvascular sonothrombolysis.

  title={Effect of acoustic conditions on microbubble-mediated microvascular sonothrombolysis.},
  author={Jonathan E Leeman and Jong Sang Kim and Francois T. H. Yu and Xucai Chen and Kang Kim and Jianjun Wang and Xianghui Chen and Flordeliza S. Villanueva and John J. Pacella},
  journal={Ultrasound in medicine & biology},
  volume={38 9},
Ultrasound (US) mediated microbubble (MB) destruction facilitates thrombolysis of the epicardial coronary artery in acute myocardial infarction (AMI) but its effect on microvascular thromboemboli remains largely unexplored. We sought to define the acoustic requirements for effective microvascular sonothrombolysis. To model microembolization, microthrombi were injected and entrapped in a 40 μm pore mesh, increasing upstream pressure, which was measured as an index of thrombus burden. MBs (2.0… CONTINUE READING


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