Effect of acidosis on transient outward potassium current in isolated rat ventricular myocytes.

@article{Hulme2000EffectOA,
  title={Effect of acidosis on transient outward potassium current in isolated rat ventricular myocytes.},
  author={Joanne T. Hulme and Clive H Orchard},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={278 1},
  pages={H50-9}
}
The effect of acidosis on the transient outward K(+) current (I(to)) of rat ventricular myocytes has been investigated using the perforated patch-clamp technique. When the holding potential was -80 mV, depolarizing pulses to potentials positive to -20 mV activated I(to) in subepicardial cells but activated little I(to) in subendocardial cells. Exposure to an acid solution (pH 6.5) had no significant effect on I(to) activated from this holding potential in either subepicardial or subendocardial… CONTINUE READING