Effect of acidosis on tension and [Ca2+]i in rat cerebral arteries: is there a role for membrane potential?

@article{Peng1998EffectOA,
  title={Effect of acidosis on tension and [Ca2+]i in rat cerebral arteries: is there a role for membrane potential?},
  author={H L Peng and Peter Errboe Jensen and Holger Nilsson and Christian Aalkjaer},
  journal={The American journal of physiology},
  year={1998},
  volume={274 2 Pt 2},
  pages={H655-62}
}
The cellular mechanism responsible for the reduction of tension in cerebral small arteries to acidosis is not known. In this study the role of smooth muscle intracellular Ca2+ concentration ([Ca2+]i) and membrane potential for the relaxation to acidosis was investigated in isolated rat cerebral small arteries. Isometric force was measured simultaneously with [Ca2+]i (fura 2) or with membrane potential (intracellular microelectrodes), and acidosis was induced by increasing PCO2 or reducing HCO3… CONTINUE READING
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