Corpus ID: 40089904

Effect of 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylic acid on gastric mucosal defensive factors and gastric secretion in rats.

@article{Ishizuka1994EffectO1,
  title={Effect of 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylic acid on gastric mucosal defensive factors and gastric secretion in rats.},
  author={Y. Ishizuka and T. Kamisaki and N. Okamoto and M. Matsuda and I. Shimazaki and I. Kimura and A. Kamiya and M. Kataoka and M. Kawashima and K. Terashima},
  journal={Arzneimittel-Forschung},
  year={1994},
  volume={44 5},
  pages={
          620-6
        }
}
  • Y. Ishizuka, T. Kamisaki, +7 authors K. Terashima
  • Published 1994
  • Chemistry, Medicine
  • Arzneimittel-Forschung
  • 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarbo xylic acid, (MAR-99, CAS 98772-05-5) (10-30 mg/kg i.g.) improved the reduction of gastric blood flow rate induced by the administration of 99.5% ethanol or acidified-acetylsalicylic acid (ASA). In addition, MAR-99 (3 x 10(-6)-3 x 10(-5) mol/l) protected dose-dependently the damage of epithelial cells induced by ulcerogenic agents such as ethanol or acidified-ASA. MAR-99 (1-10 mg/kg p.o.) prevented dose-dependently the reduction… CONTINUE READING
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