Effect of acamprosate and naltrexone, alone or in combination, on ethanol consumption.

@article{Stromberg2001EffectOA,
  title={Effect of acamprosate and naltrexone, alone or in combination, on ethanol consumption.},
  author={Michael Stromberg and Scott A. Mackler and Joseph R. Volpicelli and CharlesP. O'Brien},
  journal={Alcohol},
  year={2001},
  volume={23 2},
  pages={
          109-16
        }
}
Both acamprosate and naltrexone have demonstrated clinical utility in reducing relapse to alcohol use in recovering alcoholics. The present experiments examined the effects of acamprosate and naltrexone, either alone or in combination, on basal ethanol consumption in a limited-access model with the use of outbred Wistar rats. Naltrexone, 0.1 mg/kg, significantly reduced ethanol consumption as previously reported. Acamprosate, 50 mg/kg, did not significantly reduce ethanol consumption when… CONTINUE READING
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