Effect of abstinence challenge on brain function and cognition in smokers differs by COMT genotype

@article{Loughead2009EffectOA,
  title={Effect of abstinence challenge on brain function and cognition in smokers differs by COMT genotype},
  author={James Loughead and E. Paul Wileyto and Jeffrey N. Valdez and Paul Sanborn and Kathy X Tang and A A Strasser and Kosha Ruparel and Riju Ray and Ruben C. Gur and Caryn Lerman},
  journal={Molecular Psychiatry},
  year={2009},
  volume={14},
  pages={820-826}
}
The val allele of the catechol-O-methyltransferase (COMT) val158met polymorphism has been linked with nicotine dependence and with cognitive performance in healthy volunteers. We tested the hypothesis that the val allele is a risk factor for altered brain function and cognition during nicotine abstinence as compared with the normal smoking state. Chronic smokers (n=33) were genotyped prospectively for the COMT polymorphism for balanced selection of met/met, val/met and val/val groups. A visual… CONTINUE READING